Z-LLNle-CHO

Across CCLE and GDSC cell-line panels, response to Z-LLNle-CHO is significantly associated with the protein-level pathway activity of multiple pathways, with LUNG_SCLC cell lines showing a particularly strong set of associations.

The most reproducible Z-LLNle-CHO response-associated pathways across cancer lineages are Nucleobase-containing compound transport, Homotypic cell-cell adhesion, and Lymphocyte homeostasis, each associated with drug response in up to 7 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Z-LLNle-CHO response versus Nucleobase-containing compound transport protein-level pathway activity in LUNG_SCLC (Pearson r = 0.46).

Protein-level pathway activity biomarkers of Z-LLNle-CHO response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Nucleobase-containing compound transport →	+0.143	+0.808	<.001	.001	3	7
BLOOD_Myeloma	Homotypic cell-cell adhesion →	-0.275	-0.627	.006	.042	3	6
BONE	Lymphocyte homeostasis →	-0.343	-1.086	.011	.007	3	6
STOMACH	T cell differentiation in thymus →	-0.323	-0.536	.010	.032	3	6
STOMACH	CD8-positive, alpha-beta T cell differentiation →	-0.355	-0.536	.002	.032	3	6
LUNG_NSCLC_LUAD	Osteoclast differentiation →	+0.182	+1.386	.027	.009	3	5

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Z-LLNle-CHO response vs Nucleobase-containing compound transport — LUNG_SCLC

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