YM201636

Across CCLE and GDSC cell-line panels, response to YM201636 is significantly associated with the shRNA dependency of multiple gene dependencies, with BONE cell lines showing a particularly strong set of associations.

The most reproducible YM201636 response-associated gene dependencies across cancer lineages are OAT, TMEM104, and SH3BP5L, each associated with drug response in up to 7 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, YM201636 response versus OAT shRNA dependency in BONE (Pearson r = 0.90).

Shrna dependency biomarkers of YM201636 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene dependencie	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	OAT →	+0.205	+1.407	.032	.003	3	7
KIDNEY	TMEM104 →	+0.286	+0.433	.012	.002	3	7
STOMACH	SH3BP5L →	+0.270	+0.967	.044	.002	3	6
PANCREAS	POLR2M →	+0.193	+0.512	.007	.007	3	6
LARGE_INTESTINE	CP →	-0.230	-0.506	.011	.036	3	6
LIVER	ZNF142 →	+0.160	+1.016	.031	.040	3	6

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

YM201636 response vs OAT — BONE

Explore this scatter interactively →