YK-4-279

Across CCLE and GDSC cell-line panels, response to YK-4-279 is significantly associated with the pathway activity of multiple pathways, with LUNG_NSCLC_LUSC cell lines showing a particularly strong set of associations.

The most reproducible YK-4-279 response-associated pathways across cancer lineages are Response to unfolded protein, Endoplasmic reticulum unfolded protein response, and Regulation of exosomal secretion, each associated with drug response in up to 11 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, YK-4-279 response versus Response to unfolded protein pathway activity in LUNG_NSCLC_LUSC (Pearson r = -0.65).

Pathway activity biomarkers of YK-4-279 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Response to unfolded protein →	-0.107	-0.982	.001	.001	3	11
LUNG_NSCLC_LUSC	Endoplasmic reticulum unfolded protein response →	-0.123	-1.081	.001	<.001	3	10
LUNG_NSCLC_LUSC	Regulation of exosomal secretion →	-0.142	-1.059	.014	.032	3	10
LUNG_NSCLC_LUSC	Cellular response to unfolded protein →	-0.124	-1.318	<.001	<.001	3	9
LUNG_NSCLC_LUAD	Epidermal growth factor receptor signaling pathway →	-0.062	-0.695	.001	.007	3	9
BONE	Negative regulation of smooth muscle cell migration →	-0.158	-0.744	.025	.024	3	9

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

YK-4-279 response vs Response to unfolded protein — LUNG_NSCLC_LUSC

Explore this scatter interactively →