Y-39983

Across CCLE and GDSC cell-line panels, response to Y-39983 is significantly associated with the protein abundance of multiple proteins, with PANCREAS cell lines showing a particularly strong set of associations.

The most reproducible Y-39983 response-associated proteins across cancer lineages are UBE2R2, PSIP1, and DHRS7, each associated with drug response in up to 9 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Y-39983 response versus UBE2R2 protein abundance in PANCREAS (Pearson r = 0.74).

Protein abundance biomarkers of Y-39983 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	UBE2R2 →	+1.894	+0.899	<.001	.008	3	8
LIVER	PSIP1 →	+1.327	+0.810	.046	.027	3	8
KIDNEY	DHRS7 →	-0.883	-0.683	.008	.010	3	8
BONE	BCL2L1 →	-1.132	-0.797	<.001	.007	3	8
LUNG_NSCLC_LUSC	PITRM1 →	-1.559	-0.937	.021	<.001	3	8
PANCREAS	NCAPD2 →	+0.696	+0.582	.010	.003	3	8

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Y-39983 response vs UBE2R2 — PANCREAS

Explore this scatter interactively →