XMD8-92

Across CCLE and GDSC cell-line panels, response to XMD8-92 is significantly associated with the total protein of multiple proteins, with OVARY cell lines showing a particularly strong set of associations.

The most reproducible XMD8-92 response-associated proteins across cancer lineages are Akt, ERK2, and ACVRL1, each associated with drug response in up to 4 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, XMD8-92 response versus Akt total protein in OVARY (Pearson r = 0.51).

Total protein biomarkers of XMD8-92 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Akt →	+0.668	+0.459	.001	.002	3	4
BLOOD_Leukemia	ERK2 →	-0.501	-0.292	.022	.037	3	3
BLOOD_Leukemia	ACVRL1 →	+0.691	+0.400	.013	.026	3	3
BLOOD_Leukemia	PEA-15 →	-0.548	-0.412	.004	.012	3	3
BLOOD_Leukemia	ATM →	+0.697	+0.358	.004	.007	3	3
STOMACH	EGFR_pY1068 →	-2.097	-0.992	.005	.001	3	3

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

XMD8-92 response vs Akt — OVARY

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