XMD8-85

Across CCLE and GDSC cell-line panels, response to XMD8-85 is significantly associated with the RNA expression of multiple genes, with LUNG_NSCLC_LUAD cell lines showing a particularly strong set of associations.

The most reproducible XMD8-85 response-associated genes across cancer lineages are TAF13, ACHE, and CANT1, each associated with drug response in up to 6 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, XMD8-85 response versus TAF13 RNA expression in LUNG_NSCLC_LUAD (Pearson r = -0.67).

Rna expression biomarkers of XMD8-85 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	TAF13 →	-1.589	-0.786	.030	.011	3	6
BLOOD_Lymphoma	ACHE →	-2.336	-0.799	.004	<.001	3	6
SKIN	CANT1 →	-0.713	-1.096	.011	<.001	3	6
BLOOD_Lymphoma	CFLAR →	-2.331	-0.636	.001	.007	3	6
BLOOD_Lymphoma	C20orf27 →	+1.203	+0.569	<.001	.003	3	6
BLOOD_Lymphoma	ATP6V1E1 →	-0.764	-0.795	<.001	<.001	3	6

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

XMD8-85 response vs TAF13 — LUNG_NSCLC_LUAD

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