Wnt-C59

Across CCLE and GDSC cell-line panels, response to Wnt-C59 is significantly associated with the pathway activity of multiple pathways, with OVARY cell lines showing a particularly strong set of associations.

The most reproducible Wnt-C59 response-associated pathways across cancer lineages are Response to calcium ion, Proteinogenic amino acid metabolic process, and Regulation of plasminogen activation, each associated with drug response in up to 11 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Wnt-C59 response versus Response to calcium ion pathway activity in OVARY (Pearson r = -0.50).

Pathway activity biomarkers of Wnt-C59 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Response to calcium ion →	-0.120	-0.500	.006	.005	3	11
BLOOD_Lymphoma	Proteinogenic amino acid metabolic process →	+0.040	+0.339	.009	.005	3	10
SOFT_TISSUE	Regulation of plasminogen activation →	-0.354	-0.659	.002	.007	3	10
BONE	Oncostatin-M-mediated signaling pathway →	-0.373	-0.525	.001	.009	3	10
SOFT_TISSUE	Leukemia inhibitory factor signaling pathway →	-0.250	-0.697	.029	.021	3	10
SOFT_TISSUE	Regulation of protein maturation →	-0.210	-0.517	.022	.024	3	10

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Wnt-C59 response vs Response to calcium ion — OVARY

Explore this scatter interactively →