WZ4003

Across CCLE and GDSC cell-line panels, response to WZ4003 is significantly associated with the protein abundance of multiple proteins, with URINARY_TRACT cell lines showing a particularly strong set of associations.

The most reproducible WZ4003 response-associated proteins across cancer lineages are ZNF671, MRPL44, and FBL, each associated with drug response in up to 9 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, WZ4003 response versus ZNF671 protein abundance in URINARY_TRACT (Pearson r = -0.67).

Protein abundance biomarkers of WZ4003 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	ZNF671 →	-2.200	-1.103	.022	.045	2	9
STOMACH	MRPL44 →	+0.550	+0.639	<.001	<.001	3	8
URINARY_TRACT	FBL →	+0.523	+0.657	.004	.022	3	8
OESOPHAGUS	ZNF566 →	-1.036	-0.661	.011	.013	3	8
BLOOD_Lymphoma	SH3BGRL →	-0.793	-0.581	.006	<.001	3	8
UPPER_AERODIGESTIVE_TRACT	SMAP2 →	-2.603	-1.036	.041	.005	3	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

WZ4003 response vs ZNF671 — URINARY_TRACT

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