WH-4-023

Across CCLE and GDSC cell-line panels, response to WH-4-023 is significantly associated with the shRNA dependency of multiple gene dependencies, with LUNG_NSCLC_LUAD cell lines showing a particularly strong set of associations.

The most reproducible WH-4-023 response-associated gene dependencies across cancer lineages are STK32C, KCTD4, and POLR1D, each associated with drug response in up to 5 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, WH-4-023 response versus STK32C shRNA dependency in LUNG_NSCLC_LUAD (Pearson r = -0.72).

Shrna dependency biomarkers of WH-4-023 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene dependencie	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	STK32C →	-0.193	-2.226	.004	<.001	3	5
BREAST	KCTD4 →	+0.443	+0.635	.003	.005	3	5
CNS	POLR1D →	+0.299	+1.624	.026	.003	3	5
BLOOD_Lymphoma	KRT18 →	-0.286	-1.437	.044	.025	3	4
LUNG_NSCLC_LUAD	PCYOX1 →	-0.233	-2.283	.046	<.001	3	4
LUNG_SCLC	TMPRSS4 →	-0.242	-0.450	.009	.037	3	4

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

WH-4-023 response vs STK32C — LUNG_NSCLC_LUAD

Explore this scatter interactively →