WH-4-023

Across CCLE and GDSC cell-line panels, response to WH-4-023 is significantly associated with the total protein of multiple proteins, with BLOOD_Leukemia cell lines showing a particularly strong set of associations.

The most reproducible WH-4-023 response-associated proteins across cancer lineages are Gab2, Lck, and JNK_pT183_Y185, each associated with drug response in up to 4 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, WH-4-023 response versus Gab2 total protein in BLOOD_Leukemia (Pearson r = 0.52).

Total protein biomarkers of WH-4-023 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Gab2 →	+2.553	+1.658	<.001	.003	3	3
BREAST	Lck →	+0.960	+0.573	.010	.002	3	3
BLOOD_Leukemia	JNK_pT183_Y185 →	+0.961	+1.700	.008	.004	3	3
LARGE_INTESTINE	HSP70 →	+0.271	+0.973	.003	<.001	3	3
LARGE_INTESTINE	TAZ →	+0.507	+1.057	.002	.025	3	3
LUNG_SCLC	Rb →	+0.523	+0.590	.017	.032	2	3

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

WH-4-023 response vs Gab2 — BLOOD_Leukemia

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