WH-4-023

Across CCLE and GDSC cell-line panels, response to WH-4-023 is significantly associated with the pathway activity of multiple pathways, with OESOPHAGUS cell lines showing a particularly strong set of associations.

The most reproducible WH-4-023 response-associated pathways across cancer lineages are Regulation of translation at presynapse, Regulation of translation at presynapse, modulating synaptic transmission, and Toll-like receptor 3 signaling pathway, each associated with drug response in up to 6 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, WH-4-023 response versus Regulation of translation at presynapse pathway activity in OESOPHAGUS (Pearson r = 0.82).

Pathway activity biomarkers of WH-4-023 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Regulation of translation at presynapse →	+0.182	+1.793	.005	.015	3	6
OESOPHAGUS	Regulation of translation at presynapse, modulating synaptic transmission →	+0.182	+1.793	.005	.015	3	6
LUNG_SCLC	Toll-like receptor 3 signaling pathway →	+0.137	+0.366	.001	.036	3	6
LUNG_NSCLC_LUAD	Regulation of ferroptosis →	+0.147	+2.343	.004	<.001	3	5
BREAST	Positive regulation of vascular associated smooth muscle cell apoptotic process →	+0.260	+0.636	.048	.003	3	5
BLOOD_Leukemia	Positive regulation of interleukin-18 production →	-0.117	-1.209	.016	.005	3	5

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

WH-4-023 response vs Regulation of translation at presynapse — OESOPHAGUS

Explore this scatter interactively →