Voxtalisib

Across CCLE and GDSC cell-line panels, response to Voxtalisib is significantly associated with the total protein of multiple proteins, with UPPER_AERODIGESTIVE_TRACT cell lines showing a particularly strong set of associations.

The most reproducible Voxtalisib response-associated proteins across cancer lineages are PDK1, p27, and C-Raf(MP05-739), each associated with drug response in up to 7 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Voxtalisib response versus PDK1 total protein in UPPER_AERODIGESTIVE_TRACT (Pearson r = -0.56).

Total protein biomarkers of Voxtalisib response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	PDK1 →	-0.267	-0.385	.010	.025	3	7
STOMACH	p27 →	+0.291	+0.555	.004	.025	3	5
LARGE_INTESTINE	C-Raf(MP05-739) →	+0.405	+0.393	.037	.017	3	5
OVARY	Smad1 →	+0.253	+0.421	.017	.014	3	5
LARGE_INTESTINE	C-Raf_pS338 →	+0.110	+0.264	.028	.045	3	5
STOMACH	14-3-3_zeta →	-0.680	-0.677	.015	.005	3	4

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Voxtalisib response vs PDK1 — UPPER_AERODIGESTIVE_TRACT

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