Vismodegib

Across CCLE and GDSC cell-line panels, response to Vismodegib is significantly associated with the shRNA dependency of multiple gene dependencies, with BLOOD_Leukemia cell lines showing a particularly strong set of associations.

The most reproducible Vismodegib response-associated gene dependencies across cancer lineages are LGALS3, PCCB, and VCPIP1, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Vismodegib response versus LGALS3 shRNA dependency in BLOOD_Leukemia (Pearson r = -0.37).

Shrna dependency biomarkers of Vismodegib response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene dependencie	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	LGALS3 →	-0.125	-0.251	.033	.008	2	8
BLOOD_Leukemia	PCCB →	-0.118	-0.211	.027	.041	2	7
OVARY	VCPIP1 →	-0.233	-0.438	<.001	.003	3	6
BLOOD_Leukemia	SLC7A8 →	+0.170	+0.290	.041	.017	3	6
LIVER	ESX1 →	+0.172	+0.734	.007	.001	3	6
OVARY	MGAT1 →	+0.228	+0.443	.006	.006	3	6

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Vismodegib response vs LGALS3 — BLOOD_Leukemia

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