Vismodegib

Across CCLE and GDSC cell-line panels, response to Vismodegib is significantly associated with the shRNA pathway dependency of multiple pathways, with URINARY_TRACT cell lines showing a particularly strong set of associations.

The most reproducible Vismodegib response-associated pathways across cancer lineages are Branched-chain amino acid metabolic process, Microtubule-based transport, and Transport along microtubule, each associated with drug response in up to 7 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Vismodegib response versus Branched-chain amino acid metabolic process shRNA pathway dependency in URINARY_TRACT (Pearson r = 0.83).

Shrna pathway dependency biomarkers of Vismodegib response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Branched-chain amino acid metabolic process →	+2.021	+0.503	.002	.028	3	7
STOMACH	Microtubule-based transport →	-0.180	-0.387	.006	.040	3	7
CNS	Transport along microtubule →	-0.192	-0.592	.015	.008	3	7
KIDNEY	Mitochondrial RNA metabolic process →	+0.369	+0.430	.011	.007	3	7
OESOPHAGUS	Protein polyufmylation →	-1.459	-0.459	.004	.047	3	7
OESOPHAGUS	Protein K69-linked ufmylation →	-1.459	-0.459	.004	.047	3	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Vismodegib response vs Branched-chain amino acid metabolic process — URINARY_TRACT

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