Vismodegib

Across CCLE and GDSC cell-line panels, response to Vismodegib is significantly associated with the pathway activity of multiple pathways, with OVARY cell lines showing a particularly strong set of associations.

The most reproducible Vismodegib response-associated pathways across cancer lineages are Regulation of actin filament bundle assembly, 'de novo' UMP biosynthetic process, and Positive regulation of canonical NF-kappaB signal transduction, each associated with drug response in up to 10 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Vismodegib response versus Regulation of actin filament bundle assembly pathway activity in OVARY (Pearson r = -0.40).

Pathway activity biomarkers of Vismodegib response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Regulation of actin filament bundle assembly →	-0.062	-0.358	.003	.023	2	10
BONE	'de novo' UMP biosynthetic process →	+0.111	+0.401	.004	.001	3	9
LARGE_INTESTINE	Positive regulation of canonical NF-kappaB signal transduction →	-0.046	-0.449	.004	.008	3	9
STOMACH	rRNA transcription →	+0.131	+0.597	.001	.013	3	8
OESOPHAGUS	Epidermal growth factor receptor signaling pathway →	-0.094	-0.414	.047	.037	3	8
SOFT_TISSUE	Third ventricle development →	+0.185	+0.492	<.001	.027	3	8

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Vismodegib response vs Regulation of actin filament bundle assembly — OVARY

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