Vinorelbine

Across CCLE and GDSC cell-line panels, response to Vinorelbine is significantly associated with the RNA expression of multiple genes, with OESOPHAGUS cell lines showing a particularly strong set of associations.

The most reproducible Vinorelbine response-associated genes across cancer lineages are SPATA5L1, INPP4B, and ARFGEF2, each associated with drug response in up to 10 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Vinorelbine response versus SPATA5L1 RNA expression in OESOPHAGUS (Pearson r = 0.46).

Rna expression biomarkers of Vinorelbine response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	SPATA5L1 →	+0.734	+0.829	.005	.019	3	10
BONE	INPP4B →	-2.650	-0.985	<.001	.005	3	9
BLOOD_Myeloma	ARFGEF2 →	-1.070	-0.562	.010	.042	3	9
BONE	ABHD2 →	-1.467	-0.940	.017	.024	3	9
BLOOD_Myeloma	CTSA →	-1.497	-0.523	.014	.028	3	9
LUNG_SCLC	CHMP4B →	-0.750	-0.736	.001	.021	3	9

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Vinorelbine response vs SPATA5L1 — OESOPHAGUS

Explore this scatter interactively →