Vinorelbine

Across CCLE and GDSC cell-line panels, response to Vinorelbine is significantly associated with the pathway activity of multiple pathways, with LUNG_SCLC cell lines showing a particularly strong set of associations.

The most reproducible Vinorelbine response-associated pathways across cancer lineages are 'de novo' AMP biosynthetic process, Phosphatidylserine metabolic process, and AMP biosynthetic process, each associated with drug response in up to 10 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Vinorelbine response versus 'de novo' AMP biosynthetic process pathway activity in LUNG_SCLC (Pearson r = 0.53).

Pathway activity biomarkers of Vinorelbine response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	'de novo' AMP biosynthetic process →	+0.156	+0.795	<.001	.003	3	10
BONE	Phosphatidylserine metabolic process →	-0.120	-0.756	.021	.003	3	9
LUNG_SCLC	AMP biosynthetic process →	+0.143	+0.977	.001	<.001	3	9
SOFT_TISSUE	Regulation of glomerular mesangial cell proliferation →	-0.254	-0.381	.012	.006	3	9
UPPER_AERODIGESTIVE_TRACT	Nuclear receptor-mediated signaling pathway →	-0.077	-0.961	.018	.026	3	8
LARGE_INTESTINE	Endothelium development →	-0.147	-1.439	<.001	<.001	3	8

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Vinorelbine response vs 'de novo' AMP biosynthetic process — LUNG_SCLC

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