Vincristine

Across CCLE and GDSC cell-line panels, response to Vincristine is significantly associated with the total protein of multiple proteins, with BONE cell lines showing a particularly strong set of associations.

The most reproducible Vincristine response-associated proteins across cancer lineages are Src_pY416, MSH6, and Bap1-c-4, each associated with drug response in up to 6 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Vincristine response versus Src_pY416 total protein in BONE (Pearson r = 0.58).

Total protein biomarkers of Vincristine response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Src_pY416 →	+0.655	+1.469	.001	.005	3	6
BONE	MSH6 →	+0.894	+1.720	.021	.014	3	5
SKIN	Bap1-c-4 →	+0.388	+1.207	.003	.002	3	5
OVARY	p70-S6K →	+1.062	+1.558	.003	.001	3	5
LARGE_INTESTINE	SETD2 →	-0.665	-1.550	.005	<.001	3	5
LUNG_SCLC	p62 Lck ligand →	-1.365	-1.498	.040	.026	2	6

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Vincristine response vs Src_pY416 — BONE

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