VX-702

Across CCLE and GDSC cell-line panels, response to VX-702 is significantly associated with the shRNA pathway dependency of multiple pathways, with LUNG_NSCLC_LUSC cell lines showing a particularly strong set of associations.

The most reproducible VX-702 response-associated pathways across cancer lineages are Cellular response to iron ion, Detection of bacterium, and Visual learning, each associated with drug response in up to 7 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, VX-702 response versus Cellular response to iron ion shRNA pathway dependency in LUNG_NSCLC_LUSC (Pearson r = 0.49).

Shrna pathway dependency biomarkers of VX-702 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Cellular response to iron ion →	+1.431	+0.332	.007	.023	3	7
LIVER	Detection of bacterium →	-1.797	-0.296	.002	.023	3	7
PANCREAS	Visual learning →	+0.980	+0.258	.020	.007	3	7
OESOPHAGUS	Response to methamphetamine hydrochloride →	-1.112	-0.236	.031	.046	3	7
BONE	Type 2 immune response →	-1.329	-0.285	<.001	.041	3	6
LIVER	Meiotic cell cycle →	+0.314	+0.272	.004	.043	3	6

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

VX-702 response vs Cellular response to iron ion — LUNG_NSCLC_LUSC

Explore this scatter interactively →