VX-11e

Across CCLE and GDSC cell-line panels, response to VX-11e is significantly associated with the mutation status of multiple genes, with BLOOD_Myeloma cell lines showing a particularly strong set of associations.

The most reproducible VX-11e response-associated genes across cancer lineages are TP53, TSHZ3, and ADGRV1, each associated with drug response in up to 3 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The box plot shows the strongest observed association, VX-11e response grouped by TP53 status in BLOOD_Myeloma.

Mutation status biomarkers of VX-11e response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	TP53 →	-1.614	-0.428	.040	.025	3	3
BLOOD_Lymphoma	TSHZ3 →	-3.184	-0.495	.006	.005	3	3
BLOOD_Lymphoma	ADGRV1 →	-1.347	-0.301	.031	.044	3	3
BLOOD_Lymphoma	DCHS1 →	-2.714	-0.413	.037	.028	3	3
BLOOD_Lymphoma	NBEA →	+2.093	+0.422	.023	.008	3	3
BLOOD_Lymphoma	CSPG4 →	-3.032	-0.432	.013	.021	3	3

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

VX-11e response by TP53 status — BLOOD_Myeloma

Explore this box plot interactively →