VTP-B

Across CCLE and GDSC cell-line panels, response to VTP-B is significantly associated with the pathway activity of multiple pathways, with LUNG_SCLC cell lines showing a particularly strong set of associations.

The most reproducible VTP-B response-associated pathways across cancer lineages are Response to calcium ion, L-amino acid catabolic process, and Negative regulation of transforming growth factor beta production, each associated with drug response in up to 10 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, VTP-B response versus Response to calcium ion pathway activity in LUNG_SCLC (Pearson r = -0.44).

Pathway activity biomarkers of VTP-B response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Response to calcium ion →	-0.075	-0.272	.012	.038	2	10
SOFT_TISSUE	L-amino acid catabolic process →	+0.086	+0.238	.041	.023	3	8
OVARY	Negative regulation of transforming growth factor beta production →	-0.241	-0.468	.004	.002	3	8
LARGE_INTESTINE	Positive regulation of meiotic cell cycle phase transition →	+0.119	+0.463	<.001	.006	3	8
PANCREAS	L-amino acid metabolic process →	+0.062	+0.396	.004	.019	2	8
LARGE_INTESTINE	Receptor-mediated endocytosis of virus by host cell →	-0.134	-0.398	.026	.025	3	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

VTP-B response vs Response to calcium ion — LUNG_SCLC

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