VTP-A

Across CCLE and GDSC cell-line panels, response to VTP-A is significantly associated with the total protein of multiple proteins, with KIDNEY cell lines showing a particularly strong set of associations.

The most reproducible VTP-A response-associated proteins across cancer lineages are G6PD, Annexin_VII, and CD20, each associated with drug response in up to 6 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, VTP-A response versus G6PD total protein in KIDNEY (Pearson r = -0.67).

Total protein biomarkers of VTP-A response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	G6PD →	-1.273	-0.476	.020	.026	3	5
BLOOD_Lymphoma	Annexin_VII →	-0.537	-0.208	.017	.031	3	5
KIDNEY	CD20 →	-0.449	-0.583	.038	.037	2	6
OVARY	AMPK_pT172 →	+1.031	+0.596	.015	.036	3	5
SKIN	FRA1 →	-1.219	-0.330	.008	.001	3	5
CNS	SCD1 →	+0.481	+0.407	.041	.005	3	5

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

VTP-A response vs G6PD — KIDNEY

Explore this scatter interactively →