Uprosertib

Across CCLE and GDSC cell-line panels, response to Uprosertib is significantly associated with the shRNA dependency of multiple gene dependencies, with STOMACH cell lines showing a particularly strong set of associations.

The most reproducible Uprosertib response-associated gene dependencies across cancer lineages are PRB3, BDH1, and SERPINB8, each associated with drug response in up to 7 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Uprosertib response versus PRB3 shRNA dependency in STOMACH (Pearson r = 0.72).

Shrna dependency biomarkers of Uprosertib response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene dependencie	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	PRB3 →	+0.192	+1.424	.007	.001	3	7
OVARY	BDH1 →	+0.381	+1.512	.010	.020	2	7
OVARY	SERPINB8 →	-0.228	-1.283	.018	.009	3	6
SOFT_TISSUE	PPP3R2 →	-0.381	-1.629	.022	.009	2	7
BLOOD_Leukemia	ZSCAN16 →	+0.210	+0.651	.010	.006	3	6
URINARY_TRACT	TRPM7 →	+0.252	+1.380	.005	.001	3	6

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Uprosertib response vs PRB3 — STOMACH

Explore this scatter interactively →