UNC0379

Across CCLE and GDSC cell-line panels, response to UNC0379 is significantly associated with the mutation status of multiple genes, with PANCREAS cell lines showing a particularly strong set of associations.

The most reproducible UNC0379 response-associated genes across cancer lineages are AHNAK2, SYNE1, and FAT3, each associated with drug response in up to 3 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The box plot shows the strongest observed association, UNC0379 response grouped by AHNAK2 status in PANCREAS.

Mutation status biomarkers of UNC0379 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	AHNAK2 →	+2.906	+0.448	.014	.028	3	3
OESOPHAGUS	SYNE1 →	+1.459	+0.320	.026	.044	3	3
OESOPHAGUS	FAT3 →	+2.736	+0.367	.019	.025	3	3
LARGE_INTESTINE	TP53 →	-1.378	-0.441	.004	.027	3	3
LARGE_INTESTINE	HSPG2 →	+1.584	+0.442	.024	.016	3	3
LARGE_INTESTINE	ARID1A →	+1.874	+0.512	.020	.006	3	2

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

UNC0379 response by AHNAK2 status — PANCREAS

Explore this box plot interactively →