ULK1_4989

Across CCLE and GDSC cell-line panels, response to ULK1_4989 is significantly associated with the protein abundance of multiple proteins, with OVARY cell lines showing a particularly strong set of associations.

The most reproducible ULK1_4989 response-associated proteins across cancer lineages are SQSTM1, DAXX, and ETFB, each associated with drug response in up to 7 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, ULK1_4989 response versus SQSTM1 protein abundance in OVARY (Pearson r = -0.60).

Protein abundance biomarkers of ULK1_4989 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	SQSTM1 →	-1.160	-0.389	.002	.020	3	7
CNS	DAXX →	+0.675	+0.614	.016	.016	3	7
LIVER	ETFB →	-0.925	-1.276	.029	.026	3	7
CNS	COL1A1 →	+2.145	+0.864	.004	.001	3	7
CNS	SMARCC1 →	+0.666	+0.828	.001	<.001	3	7
PANCREAS	MCU →	-0.851	-0.438	.014	.034	2	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ULK1_4989 response vs SQSTM1 — OVARY

Explore this scatter interactively →