Tubastatin A

Across CCLE and GDSC cell-line panels, response to Tubastatin A is significantly associated with the shRNA pathway dependency of multiple pathways, with SOFT_TISSUE cell lines showing a particularly strong set of associations.

The most reproducible Tubastatin A response-associated pathways across cancer lineages are Lagging strand elongation, Protein import into peroxisome matrix, receptor recycling, and Double-strand break repair, each associated with drug response in up to 7 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Tubastatin A response versus Lagging strand elongation shRNA pathway dependency in SOFT_TISSUE (Pearson r = -0.83).

Shrna pathway dependency biomarkers of Tubastatin A response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Lagging strand elongation →	-0.197	-0.598	.014	.003	3	7
LARGE_INTESTINE	Protein import into peroxisome matrix, receptor recycling →	-1.095	-0.672	.003	<.001	3	7
CNS	Double-strand break repair →	-0.176	-0.557	.003	.013	3	7
STOMACH	Positive regulation of voltage-gated calcium channel activity →	+1.931	+0.679	<.001	.004	3	7
STOMACH	DNA-templated DNA replication →	-0.184	-0.362	.007	.031	3	7
SKIN	Aminoglycan metabolic process →	+0.615	+0.430	.038	.007	3	6

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Tubastatin A response vs Lagging strand elongation — SOFT_TISSUE

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