Trichostatin A

Across CCLE and GDSC cell-line panels, response to Trichostatin A is significantly associated with the mutation status of multiple genes, with LUNG_NSCLC_LUAD cell lines showing a particularly strong set of associations.

The most reproducible Trichostatin A response-associated genes across cancer lineages are THBS2, TNC, and KRT83, each associated with drug response in up to 3 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The box plot shows the strongest observed association, Trichostatin A response grouped by THBS2 status in LUNG_NSCLC_LUAD.

Mutation status biomarkers of Trichostatin A response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	THBS2 →	-3.169	-0.437	.011	.008	3	3
LARGE_INTESTINE	TNC →	-2.070	-0.357	.020	.027	3	3
LUNG_NSCLC_LUAD	KRT83 →	-3.000	-0.487	.025	.005	3	2
LUNG_NSCLC_LUAD	ANKRD30B →	-2.169	-0.489	.041	.002	3	2
SKIN	RYR2 →	-1.528	-0.287	.009	.007	3	2
LUNG_SCLC	DNAH2 →	-2.941	-0.469	.023	.002	3	2

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Trichostatin A response by THBS2 status — LUNG_NSCLC_LUAD

Explore this box plot interactively →