Tretinoin

Across CCLE and GDSC cell-line panels, response to Tretinoin is significantly associated with the total protein of multiple proteins, with BLOOD_Lymphoma cell lines showing a particularly strong set of associations.

The most reproducible Tretinoin response-associated proteins across cancer lineages are VAV1, c-Myc, and A-Raf_pS299, each associated with drug response in up to 3 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Tretinoin response versus VAV1 total protein in BLOOD_Lymphoma (Pearson r = -0.85).

Total protein biomarkers of Tretinoin response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	VAV1 →	-0.875	-0.434	.007	.008	3	3
SKIN	c-Myc →	+0.707	+0.494	.011	.008	3	3
SKIN	A-Raf_pS299 →	-0.463	-0.567	.024	.004	3	2
SKIN	Heregulin →	-0.235	-0.554	.016	.014	3	2
BLOOD_Leukemia	p27 →	-0.419	-0.836	.023	.029	3	2
SKIN	PCNA →	+0.422	+0.419	.004	.005	3	2

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Tretinoin response vs VAV1 — BLOOD_Lymphoma

Explore this scatter interactively →