Tozasertib

Across CCLE and GDSC cell-line panels, response to Tozasertib is significantly associated with the total protein of multiple proteins, with LUNG_NSCLC_LUAD cell lines showing a particularly strong set of associations.

The most reproducible Tozasertib response-associated proteins across cancer lineages are RBM15, HER2_pY1248, and HER3, each associated with drug response in up to 3 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Tozasertib response versus RBM15 total protein in LUNG_NSCLC_LUAD (Pearson r = 0.82).

Total protein biomarkers of Tozasertib response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	RBM15 →	+1.361	+1.363	.005	.017	3	3
BREAST	HER2_pY1248 →	-1.553	-0.656	.043	.011	3	2
BREAST	HER3 →	-0.599	-0.709	.023	.014	2	3
BREAST	INPP4B →	-0.347	-0.615	.012	.032	3	2
BREAST	PREX1 →	-1.928	-0.814	<.001	.001	3	2
BREAST	PTEN →	-1.770	-0.708	.006	.018	3	2

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Tozasertib response vs RBM15 — LUNG_NSCLC_LUAD

Explore this scatter interactively →