Tozasertib

Across CCLE and GDSC cell-line panels, response to Tozasertib is significantly associated with the shRNA pathway dependency of multiple pathways, with LUNG_NSCLC_LUAD cell lines showing a particularly strong set of associations.

The most reproducible Tozasertib response-associated pathways across cancer lineages are Regulation of mitophagy, Negative regulation of sister chromatid cohesion, and Mitotic spindle assembly, each associated with drug response in up to 4 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Tozasertib response versus Regulation of mitophagy shRNA pathway dependency in LUNG_NSCLC_LUAD (Pearson r = -0.51).

Shrna pathway dependency biomarkers of Tozasertib response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Regulation of mitophagy →	-0.142	-0.866	.043	.029	3	4
LUNG_NSCLC_LUAD	Negative regulation of sister chromatid cohesion →	-0.357	-1.100	.014	.030	3	4
BLOOD_Leukemia	Mitotic spindle assembly →	-0.226	-1.479	.025	.028	3	4
SKIN	Spindle assembly →	-0.229	-0.648	.002	.010	3	4
BLOOD_Leukemia	Positive regulation of NLRP3 inflammasome complex assembly →	+0.470	+1.479	.030	.028	3	4
BLOOD_Leukemia	Endodermal cell differentiation →	+0.329	+1.479	.007	.028	3	4

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Tozasertib response vs Regulation of mitophagy — LUNG_NSCLC_LUAD

Explore this scatter interactively →