Torin 2

Across CCLE and GDSC cell-line panels, response to Torin 2 is significantly associated with the RNA expression of multiple genes, with LIVER cell lines showing a particularly strong set of associations.

The most reproducible Torin 2 response-associated genes across cancer lineages are USP31, VSIR, and IRAK2, each associated with drug response in up to 9 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Torin 2 response versus USP31 RNA expression in LIVER (Pearson r = 0.65).

Rna expression biomarkers of Torin 2 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	USP31 →	+0.714	+1.785	.024	.012	3	9
KIDNEY	VSIR →	-2.222	-1.824	.019	.012	3	9
STOMACH	IRAK2 →	-2.048	-1.374	.001	.004	3	8
STOMACH	POLD4 →	-1.811	-1.186	.006	.021	3	8
BONE	CLCF1 →	-2.529	-0.502	.008	.007	3	8
BONE	CD44 →	-4.620	-0.504	.004	.005	3	8

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Torin 2 response vs USP31 — LIVER

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