Torin 2

Across CCLE and GDSC cell-line panels, response to Torin 2 is significantly associated with the pathway activity of multiple pathways, with CNS cell lines showing a particularly strong set of associations.

The most reproducible Torin 2 response-associated pathways across cancer lineages are Unsaturated fatty acid metabolic process, Transepithelial water transport, and Germ cell migration, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Torin 2 response versus Unsaturated fatty acid metabolic process pathway activity in CNS (Pearson r = -0.45).

Pathway activity biomarkers of Torin 2 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Unsaturated fatty acid metabolic process →	-0.112	-0.669	.004	.007	3	8
BONE	Transepithelial water transport →	+1.810	+0.441	.004	.020	3	8
SKIN	Germ cell migration →	+0.572	+0.693	.020	.004	3	8
SOFT_TISSUE	Negative regulation of G2/M transition of mitotic cell cycle →	+0.050	+1.009	.019	.033	3	8
SOFT_TISSUE	Negative regulation of mitotic cell cycle phase transition →	+0.051	+1.072	.013	.016	3	8
BONE	Negative regulation of gene expression via chromosomal CpG island methylation →	+0.175	+0.595	.011	.011	3	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Torin 2 response vs Unsaturated fatty acid metabolic process — CNS

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