Tivozanib

Across CCLE and GDSC cell-line panels, response to Tivozanib is significantly associated with the mutation status of multiple genes, with LARGE_INTESTINE cell lines showing a particularly strong set of associations.

The most reproducible Tivozanib response-associated genes across cancer lineages are NOTCH1, FLG, and PCDHB5, each associated with drug response in up to 4 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The box plot shows the strongest observed association, Tivozanib response grouped by NOTCH1 status in LARGE_INTESTINE.

Mutation status biomarkers of Tivozanib response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NOTCH1 →	+1.932	+0.180	.036	.040	3	4
STOMACH	FLG →	+3.321	+0.201	<.001	.040	3	3
SKIN	PCDHB5 →	+2.859	+0.174	.024	.011	3	3
LARGE_INTESTINE	CDH23 →	+2.295	+0.194	.003	.019	3	3
LARGE_INTESTINE	USP34 →	+1.710	+0.181	.012	.030	3	3
LARGE_INTESTINE	DNHD1 →	+2.125	+0.185	.012	.031	3	3

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Tivozanib response by NOTCH1 status — LARGE_INTESTINE

Explore this box plot interactively →