Teniposide

Across CCLE and GDSC cell-line panels, response to Teniposide is significantly associated with the protein abundance of multiple proteins, with LIVER cell lines showing a particularly strong set of associations.

The most reproducible Teniposide response-associated proteins across cancer lineages are RPL12, RPS5, and ENY2, each associated with drug response in up to 9 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Teniposide response versus RPL12 protein abundance in LIVER (Pearson r = 0.71).

Protein abundance biomarkers of Teniposide response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	RPL12 →	+0.622	+1.267	.002	.012	3	9
LIVER	RPS5 →	+0.725	+0.919	<.001	.022	3	9
PANCREAS	ENY2 →	+0.713	+0.792	.003	.048	3	9
PANCREAS	ENDOD1 →	-2.964	-1.357	<.001	.004	3	9
PANCREAS	ATP6V0D1 →	-1.006	-1.009	.024	.017	3	9
LUNG_SCLC	APMAP →	-1.065	-0.953	<.001	.001	3	9

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Teniposide response vs RPL12 — LIVER

Explore this scatter interactively →