Temsirolimus

Across CCLE and GDSC cell-line panels, response to Temsirolimus is significantly associated with the total protein of multiple proteins, with BONE cell lines showing a particularly strong set of associations.

The most reproducible Temsirolimus response-associated proteins across cancer lineages are Cyclin-E1, Chk2, and Gab2, each associated with drug response in up to 5 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Temsirolimus response versus Cyclin-E1 total protein in BONE (Pearson r = -0.82).

Total protein biomarkers of Temsirolimus response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Cyclin-E1 →	-1.805	-1.153	.009	.002	3	5
BONE	Chk2 →	+0.984	+0.734	.034	.045	3	5
URINARY_TRACT	Gab2 →	-2.052	-0.650	.009	.024	3	5
SOFT_TISSUE	Rab25 →	+0.445	+1.674	.038	.002	3	4
URINARY_TRACT	Src_pY527 →	+1.215	+0.699	.008	.012	3	4
OESOPHAGUS	Acetyl-a-Tubulin-Lys40 →	+0.929	+0.706	.008	.008	3	4

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Temsirolimus response vs Cyclin-E1 — BONE

Explore this scatter interactively →