Temsirolimus

Across CCLE and GDSC cell-line panels, response to Temsirolimus is significantly associated with the protein abundance of multiple proteins, with OVARY cell lines showing a particularly strong set of associations.

The most reproducible Temsirolimus response-associated proteins across cancer lineages are PSMC2, PABPC1, and TXNL1, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Temsirolimus response versus PSMC2 protein abundance in OVARY (Pearson r = 0.35).

Protein abundance biomarkers of Temsirolimus response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	PSMC2 →	+0.658	+0.598	.028	.011	3	8
LIVER	PABPC1 →	+0.965	+0.648	.001	.007	3	8
LARGE_INTESTINE	TXNL1 →	+1.009	+0.570	.035	.010	3	8
STOMACH	EPRS1 →	+0.588	+1.021	.012	.041	3	8
LIVER	DDX1 →	+0.567	+0.683	.033	.002	3	8
LUNG_SCLC	RPS29 →	+0.590	+0.607	.011	.001	3	8

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Temsirolimus response vs PSMC2 — OVARY

Explore this scatter interactively →