Tamoxifen

Across CCLE and GDSC cell-line panels, response to Tamoxifen is significantly associated with the mutation status of multiple genes, with LARGE_INTESTINE cell lines showing a particularly strong set of associations.

The most reproducible Tamoxifen response-associated genes across cancer lineages are AHNAK2, PKHD1L1, and FLG, each associated with drug response in up to 3 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The box plot shows the strongest observed association, Tamoxifen response grouped by AHNAK2 status in LARGE_INTESTINE.

Mutation status biomarkers of Tamoxifen response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	AHNAK2 →	+1.874	+0.343	.009	.017	3	3
BREAST	PKHD1L1 →	+2.914	+0.311	.012	.028	3	2
STOMACH	FLG →	+2.584	+0.397	.049	.044	3	2
SKIN	KIAA1549 →	+1.977	+0.365	.012	.028	3	2
SKIN	PIEZO2 →	+2.425	+0.553	.008	.001	3	2
SKIN	UGT3A2 →	+3.103	+0.564	.010	.003	3	2

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Tamoxifen response by AHNAK2 status — LARGE_INTESTINE

Explore this box plot interactively →