Tamoxifen

Across CCLE and GDSC cell-line panels, response to Tamoxifen is significantly associated with the pathway activity of multiple pathways, with OVARY cell lines showing a particularly strong set of associations.

The most reproducible Tamoxifen response-associated pathways across cancer lineages are Cajal body organization, Regulation of angiogenesis, and RNA folding, each associated with drug response in up to 10 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Tamoxifen response versus Cajal body organization pathway activity in OVARY (Pearson r = 0.46).

Pathway activity biomarkers of Tamoxifen response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Cajal body organization →	+0.120	+0.712	.015	.011	3	10
LUNG_NSCLC_LUSC	Regulation of angiogenesis →	-0.114	-0.710	.004	.014	3	9
LARGE_INTESTINE	RNA folding →	+0.082	+0.415	.017	.025	3	9
LUNG_SCLC	Amino acid activation →	+0.063	+0.473	.011	.021	3	9
LUNG_SCLC	tRNA aminoacylation →	+0.063	+0.473	.011	.021	3	9
LUNG_NSCLC_LUSC	Positive regulation of angiogenesis →	-0.117	-0.617	.013	.033	3	9

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Tamoxifen response vs Cajal body organization — OVARY

Explore this scatter interactively →