Talazoparib

Across CCLE and GDSC cell-line panels, response to Talazoparib is significantly associated with the protein-level pathway activity of multiple pathways, with PANCREAS cell lines showing a particularly strong set of associations.

The most reproducible Talazoparib response-associated pathways across cancer lineages are Organic acid transport, Carboxylic acid transport, and Positive regulation of exocytosis, each associated with drug response in up to 9 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Talazoparib response versus Organic acid transport protein-level pathway activity in PANCREAS (Pearson r = -0.52).

Protein-level pathway activity biomarkers of Talazoparib response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Organic acid transport →	-0.253	-0.631	<.001	.003	3	9
PANCREAS	Carboxylic acid transport →	-0.253	-0.631	<.001	.003	3	9
BONE	Positive regulation of exocytosis →	-0.360	-2.189	<.001	<.001	3	8
LUNG_NSCLC_LUSC	Sphingolipid catabolic process →	-1.164	-0.798	.029	.008	3	8
SOFT_TISSUE	Axo-dendritic transport →	-0.197	-1.175	.023	.011	3	8
OVARY	Golgi transport vesicle coating →	-0.171	-0.975	<.001	<.001	3	8

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Talazoparib response vs Organic acid transport — PANCREAS

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