THZ-2-102-1

Across CCLE and GDSC cell-line panels, response to THZ-2-102-1 is significantly associated with the protein abundance of multiple proteins, with LIVER cell lines showing a particularly strong set of associations.

The most reproducible THZ-2-102-1 response-associated proteins across cancer lineages are CLMN, NQO1, and TMF1, each associated with drug response in up to 9 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, THZ-2-102-1 response versus CLMN protein abundance in LIVER (Pearson r = -0.74).

Protein abundance biomarkers of THZ-2-102-1 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	CLMN →	-2.102	-1.445	.012	.010	3	9
LUNG_NSCLC_LUSC	NQO1 →	-2.310	-1.415	.044	.003	3	9
URINARY_TRACT	TMF1 →	-0.762	-1.159	.007	.032	3	9
BONE	ASPH →	-1.828	-2.555	.001	<.001	3	8
PANCREAS	BUD31 →	+0.442	+1.512	.002	.002	3	8
PANCREAS	MVP →	-1.671	-1.364	.004	.022	3	8

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

THZ-2-102-1 response vs CLMN — LIVER

Explore this scatter interactively →