THZ-1-87

Across CCLE and GDSC cell-line panels, response to THZ-1-87 is significantly associated with the shRNA dependency of multiple gene dependencies, with LARGE_INTESTINE cell lines showing a particularly strong set of associations.

The most reproducible THZ-1-87 response-associated gene dependencies across cancer lineages are PLP2, ASB18, and LILRB4, each associated with drug response in up to 3 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, THZ-1-87 response versus PLP2 shRNA dependency in LARGE_INTESTINE (Pearson r = -0.71).

Shrna dependency biomarkers of THZ-1-87 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene dependencie	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PLP2 →	-0.256	-1.526	.022	.017	3	3
LARGE_INTESTINE	ASB18 →	+0.175	+0.943	.028	.022	3	3
BREAST	LILRB4 →	+0.275	+1.370	.002	.015	3	3
BREAST	TUBB →	+0.910	+2.120	.030	.034	3	3
LARGE_INTESTINE	ERBB2 →	-0.154	-1.081	.026	.021	3	3
LARGE_INTESTINE	FDPS →	-0.339	-1.644	.003	.001	3	3

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

THZ-1-87 response vs PLP2 — LARGE_INTESTINE

Explore this scatter interactively →