THR-102

Across CCLE and GDSC cell-line panels, response to THR-102 is significantly associated with the mutation status of multiple genes, with LUNG_NSCLC_LUAD cell lines showing a particularly strong set of associations.

The most reproducible THR-102 response-associated genes across cancer lineages are NAV3, PKD1, and HERC2, each associated with drug response in up to 3 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The box plot shows the strongest observed association, THR-102 response grouped by NAV3 status in LUNG_NSCLC_LUAD.

Mutation status biomarkers of THR-102 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	NAV3 →	+2.115	+0.259	.004	.022	3	2
LUNG_NSCLC_LUAD	PKD1 →	+2.321	+0.295	.017	.016	3	2
LUNG_NSCLC_LUAD	HERC2 →	+1.874	+0.292	.024	.012	3	2
BLOOD_Leukemia	LAMA5 →	+2.087	+0.153	.025	.048	3	2
LARGE_INTESTINE	BEND3 →	+3.307	+0.303	.003	.018	3	2
LARGE_INTESTINE	NCKAP5 →	+1.722	+0.237	.010	.036	3	2

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

THR-102 response by NAV3 status — LUNG_NSCLC_LUAD

Explore this box plot interactively →