THR-101

Across CCLE and GDSC cell-line panels, response to THR-101 is significantly associated with the shRNA pathway dependency of multiple pathways, with LIVER cell lines showing a particularly strong set of associations.

The most reproducible THR-101 response-associated pathways across cancer lineages are Protein localization to ciliary membrane, Negative regulation of glycoprotein biosynthetic process, and Maternal behavior, each associated with drug response in up to 7 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, THR-101 response versus Protein localization to ciliary membrane shRNA pathway dependency in LIVER (Pearson r = 0.74).

Shrna pathway dependency biomarkers of THR-101 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Protein localization to ciliary membrane →	+1.400	+0.660	.002	.040	3	6
LARGE_INTESTINE	Negative regulation of glycoprotein biosynthetic process →	+1.033	+0.560	.008	.008	3	6
LARGE_INTESTINE	Maternal behavior →	+1.145	+0.542	.010	.040	3	6
LARGE_INTESTINE	Positive regulation of growth hormone receptor signaling pathway →	-1.120	-0.647	.023	.002	3	6
LARGE_INTESTINE	Parental behavior →	+1.145	+0.542	.010	.040	3	6
OESOPHAGUS	Cellular response to anisomycin →	-1.026	-0.379	.034	.031	3	6

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

THR-101 response vs Protein localization to ciliary membrane — LIVER

Explore this scatter interactively →