TAF1_5496

Across CCLE and GDSC cell-line panels, response to TAF1_5496 is significantly associated with the total protein of multiple proteins, with BREAST cell lines showing a particularly strong set of associations.

The most reproducible TAF1_5496 response-associated proteins across cancer lineages are Heregulin, PAI-1, and SETD2, each associated with drug response in up to 7 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, TAF1_5496 response versus Heregulin total protein in BREAST (Pearson r = -0.36).

Total protein biomarkers of TAF1_5496 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Heregulin →	-0.335	-0.851	.040	.045	2	7
BREAST	PAI-1 →	-1.508	-0.666	.016	.007	3	6
BREAST	SETD2 →	-0.374	-1.272	.011	.001	3	5
OVARY	FASN →	+1.004	+0.915	.001	.002	3	5
LIVER	Caveolin-1 →	-5.257	-1.375	<.001	.036	3	5
PANCREAS	FRA1 →	-1.234	-1.321	.017	.003	2	6

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TAF1_5496 response vs Heregulin — BREAST

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