TAF1_5496

Across CCLE and GDSC cell-line panels, response to TAF1_5496 is significantly associated with the mutation status of multiple genes, with OVARY cell lines showing a particularly strong set of associations.

The most reproducible TAF1_5496 response-associated genes across cancer lineages are MUC16, TPR, and ADGRG4, each associated with drug response in up to 4 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The box plot shows the strongest observed association, TAF1_5496 response grouped by MUC16 status in OVARY.

Mutation status biomarkers of TAF1_5496 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	MUC16 →	-0.700	-0.749	.039	.035	3	4
BREAST	TPR →	+3.070	+0.657	.008	.039	3	3
LUNG_SCLC	ADGRG4 →	-2.714	-0.587	.037	.009	3	3
BLOOD_Leukemia	CACNA1I →	+2.999	+0.530	.026	.003	3	3
BLOOD_Leukemia	KMT2C →	+2.169	+0.451	.032	.002	3	3
LUNG_NSCLC_LUAD	DNAH9 →	+2.807	+0.550	.035	.008	3	2

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TAF1_5496 response by MUC16 status — OVARY

Explore this box plot interactively →