T0901317

Across CCLE and GDSC cell-line panels, response to T0901317 is significantly associated with the mutation status of multiple genes, with BLOOD_Lymphoma cell lines showing a particularly strong set of associations.

The most reproducible T0901317 response-associated genes across cancer lineages are KIAA1109, SMARCA4, and C2CD3, each associated with drug response in up to 3 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The box plot shows the strongest observed association, T0901317 response grouped by KIAA1109 status in BLOOD_Lymphoma.

Mutation status biomarkers of T0901317 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	KIAA1109 →	-2.707	-0.480	.035	.016	3	3
LARGE_INTESTINE	SMARCA4 →	+2.011	+0.274	.007	.010	3	3
LARGE_INTESTINE	C2CD3 →	+1.691	+0.230	.021	.028	3	3
LARGE_INTESTINE	WNK1 →	+2.252	+0.320	.001	.001	3	3
LARGE_INTESTINE	ABCC9 →	+1.722	+0.316	.040	.004	3	3
LARGE_INTESTINE	CADPS2 →	+2.914	+0.230	.012	.044	3	3

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

T0901317 response by KIAA1109 status — BLOOD_Lymphoma

Explore this box plot interactively →