Staurosporine

Across CCLE and GDSC cell-line panels, response to Staurosporine is significantly associated with the protein abundance of multiple proteins, with BONE cell lines showing a particularly strong set of associations.

The most reproducible Staurosporine response-associated proteins across cancer lineages are P4HA2, RIDA, and MRPS36, each associated with drug response in up to 11 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Staurosporine response versus P4HA2 protein abundance in BONE (Pearson r = 0.68).

Protein abundance biomarkers of Staurosporine response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	P4HA2 →	+2.227	+0.493	<.001	<.001	3	11
BLOOD_Myeloma	RIDA →	-2.145	-1.022	.005	.010	3	9
LUNG_SCLC	MRPS36 →	-0.816	-0.608	<.001	<.001	3	9
BREAST	MCCC2 →	-1.355	-1.007	.001	<.001	3	9
PANCREAS	ECI1 →	-1.232	-0.694	.003	.002	3	9
LIVER	ETFB →	-1.118	-1.021	.013	.014	3	9

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Staurosporine response vs P4HA2 — BONE

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