Staurosporine

Across CCLE and GDSC cell-line panels, response to Staurosporine is significantly associated with the shRNA pathway dependency of multiple pathways, with LUNG_SCLC cell lines showing a particularly strong set of associations.

The most reproducible Staurosporine response-associated pathways across cancer lineages are Proximal/distal pattern formation involved in nephron development, Specification of nephron tubule identity, and Zinc ion import across plasma membrane, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Staurosporine response versus Proximal/distal pattern formation involved in nephron development shRNA pathway dependency in LUNG_SCLC (Pearson r = -0.47).

Shrna pathway dependency biomarkers of Staurosporine response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Proximal/distal pattern formation involved in nephron development →	-1.079	-0.548	.032	.047	3	8
LUNG_SCLC	Specification of nephron tubule identity →	-1.079	-0.548	.032	.047	3	8
LARGE_INTESTINE	Zinc ion import across plasma membrane →	-1.061	-0.424	.004	.044	3	8
SOFT_TISSUE	Epidermis development →	-1.880	-0.690	.001	.005	3	7
BLOOD_Leukemia	Vertebrate eye-specific patterning →	+0.862	+0.798	.015	.006	3	7
OVARY	Desmosome organization →	-1.254	-0.776	.002	.001	3	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Staurosporine response vs Proximal/distal pattern formation involved in nephron development — LUNG_SCLC

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