Sinularin

Across CCLE and GDSC cell-line panels, response to Sinularin is significantly associated with the shRNA dependency of multiple gene dependencies, with CNS cell lines showing a particularly strong set of associations.

The most reproducible Sinularin response-associated gene dependencies across cancer lineages are NDUFB5, PCDH9, and IKZF5, each associated with drug response in up to 7 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Sinularin response versus NDUFB5 shRNA dependency in CNS (Pearson r = 0.71).

Shrna dependency biomarkers of Sinularin response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene dependencie	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	NDUFB5 →	+0.372	+0.531	.009	.019	3	7
CNS	PCDH9 →	+0.268	+0.615	.005	.007	3	7
OVARY	IKZF5 →	+0.182	+0.481	.017	.013	3	7
SOFT_TISSUE	MCL1 →	+0.678	+0.513	<.001	.030	3	7
BLOOD_Lymphoma	GDF15 →	-0.440	-1.105	.016	.016	3	7
SOFT_TISSUE	CKMT2 →	+0.440	+0.683	<.001	.001	3	6

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Sinularin response vs NDUFB5 — CNS

Explore this scatter interactively →