Sinularin

Across CCLE and GDSC cell-line panels, response to Sinularin is significantly associated with the RNA expression of multiple genes, with LIVER cell lines showing a particularly strong set of associations.

The most reproducible Sinularin response-associated genes across cancer lineages are AKR1C1, LPAR6, and GPHN, each associated with drug response in up to 9 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Sinularin response versus AKR1C1 RNA expression in LIVER (Pearson r = -0.56).

Rna expression biomarkers of Sinularin response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	AKR1C1 →	-4.855	-0.754	.006	.009	3	9
LIVER	LPAR6 →	-2.075	-0.719	.008	.006	3	8
LUNG_NSCLC_LUAD	GPHN →	+0.628	+0.548	.006	<.001	3	8
SKIN	PHB2 →	+0.560	+0.368	.009	.035	3	8
LUNG_SCLC	MCAT →	+0.956	+0.557	.008	.007	3	8
BONE	ABLIM3 →	-3.682	-0.352	<.001	.022	2	9

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Sinularin response vs AKR1C1 — LIVER

Explore this scatter interactively →